Latest research in Nature: "a Gram negative selective antibiotic that protects the gut microbiota"

The latest research in Nature: A novel antibiotic - "Lolamicin, a Gram negative selective antibiotic that protects the gut microbiota". The author team includes Kristen A. Mu ñ oz, Rebecca J. Ulrich, Archit K. Vasan, and others.
Infections caused by Gram negative bacteria are becoming increasingly common and are typically treated with broad-spectrum antibiotics, but this can disrupt the gut microbiota and increase the risk of secondary infections. Therefore, there is an urgent need for an antibiotic that can selectively target Gram negative bacteria and distinguish between pathogenic and symbiotic bacteria.
The discovery of the new antibiotic Lolamicin: It specifically targets the lipoprotein transport system of Gram negative bacteria, is active against over 130 clinical isolates of multidrug-resistant bacteria, and has shown efficacy in various mouse models of acute pneumonia and sepsis infections. Lolamicin exhibits low sequence homology in selectively killing pathogenic Gram negative bacteria, and this dual selectivity strategy can serve as a blueprint for developing protective antibiotics for other microbial communities.
The impact on gut microbiota: Disruption of gut microbiota caused by antibiotic treatment may lead to increased susceptibility to opportunistic pathogens such as Clostridium difficile, as well as increased risk of gastrointestinal, renal, and hematological abnormalities. Lolamicin has no significant effect on the gut microbiota in mice and can prevent secondary infection of Clostridium difficile.
The mechanism of action of Lolamicin: Through molecular modeling and experimental research, the binding site of Lolamicin has been determined, and the basis of LolCDE complex inhibition has been further understood.
In vivo efficacy of Lolamicin: In mouse models, Lolamicin has shown good tolerability and efficacy through intraperitoneal injection and oral administration.


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